Loyola University Chicago · PhysiologyEstrogen and MicroRNA Research Unit
Toni R. Pak · Chicago, Illinois
Research Focus
Dr. Toni R. Pak's lab at Loyola University Chicago explores the relationship between estrogen and microRNA expression in the context of Alzheimer's disease, particularly how these factors differ between sexes. The lab investigates how estrogen influences the regulation and stability of microRNAs in women's brains as they age, with the goal of uncovering mechanisms that could lead to better treatments for Alzheimer's disease.
Alzheimer's diseasemicroRNAsestrogenaged brainsex differences
Research Aims
3AIM 01Investigate how estrogen regulates microRNA stability across different ages in the brain.
AIM 02Explore mechanisms by which specific microRNAs are regulated post-transcriptionally by estrogen.
AIM 03Assess how estrogen influences the subcellular localization of microRNAs in relation to Alzheimer's disease.
Skills the Lab Values
PCRmiRNA degradation assaysproteomicscell cultureWestern blotRNA sequencingsubcellular localization techniquesdata analysis in biological systems
Output against the department
Publications72bottom 15% of dept.242nd of 286
this lab
most publishedleast published
Citations1.6kbottom 8% of dept.262nd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.