Case Western Reserve University · BiologyT Cell Neuroimmunology Lab
Aaron Burberry · Cleveland, Ohio
Research Focus
Dr. Aaron Burberry's lab at Case Western Reserve University focuses on understanding the role of T cells in Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). The research aims to uncover how genetic mutations, particularly in the C9ORF72 gene, and environmental factors such as gut bacteria impact T cell behavior and contribute to disease progression. By exploring these mechanisms, the lab hopes to identify new therapeutic strategies and biomarkers for these neurodegenerative disorders.
Frontotemporal DementiaAlzheimer's DiseaseT cell functionC9ORF72 mutationneuroinflammationgut microbiomeautoimmunitytherapeutic targets
Research Aims
3AIM 01Investigate how C9ORF72 functions within T cells to influence their fate and function.
AIM 02Examine how the C9ORF72 genotype affects T cell responses to gut microbes.
AIM 03Assess the relationship between pro-inflammatory cytokine IL-17A and neural inflammation in the context of C9ORF72 mutations.
Skills the Lab Values
PCRcell culturemouse modelsflow cytometryWestern blotgenetic analysisimmunohistochemistrybioinformaticsRNA extraction
Output against the department
Publications25bottom 3% of dept.1,003rd of 1,033
this lab
most publishedleast published
Citations3.0kbottom 23% of dept.798th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.