Baylor College of Medicine · GeneticsErwin Lab
Graham Scott Erwin · Houston, Texas
Research Focus
Dr. Graham Scott Erwin's lab at Baylor College of Medicine focuses on developing innovative tools for genomic medicine. They are creating new classes of small, cell-permeable molecules to edit specific DNA sequences, addressing challenges in treating genetic disorders, especially those involving repetitive DNA. By rationally designing these genome regulators, the lab aims to enhance precision medicine and make new therapeutic strategies accessible to researchers.
genome editinggenetic disordersDNA-binding ligandssmall cell-permeable editorsprecision medicine
Research Aims
3AIM 01Develop small cell-permeable genome regulators that can target specific DNA sequences.
AIM 02Create bifunctional polyamides for editing tandem repeats in cells and animal models.
AIM 03Democratize access to genome editing tools for biologists.
Skills the Lab Values
DNA sequencingmolecular cloningcell cultureanimal modelssynthetic chemistrygenome editing techniquespolyamide synthesisbiological assaysbioinformatics
Output against the department
Publications24bottom 2% of dept.252nd of 259
this lab
most publishedleast published
Citations1.0kbottom 5% of dept.247th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.