Yale University · BiochemistryHolley Development Lab
Scott A Holley · New Haven, Connecticut
Research Focus
Scott Holley's lab at Yale University studies how the body of zebrafish develops, focusing on understanding the early stages of spinal column formation. Using zebrafish as a model organism, the research explores the mechanisms behind human developmental issues, such as scoliosis and spina bifida. The lab combines various techniques like genetics and live imaging to uncover how cells interact and organize during development, contributing to a more profound understanding of biological order and developmental stability.
zebrafishspinal column developmentembryologybiomechanicscell adhesionmorphogenesisdevelopmental biologyquantitative analysis
Research Aims
5AIM 01Investigate the mechanisms behind body elongation in zebrafish.
AIM 02Study the role of cell adhesion proteins in development.
AIM 03Analyze the interactions of different tissues during embryonic development.
AIM 04Explore how cell state transitions contribute to developmental stability.
AIM 05Understand the mechanical information's effect on cell behavior during development.
Skills the Lab Values
live imaginggeneticscell culturein vivo experimentscomputational modelingsingle molecule biophysicsdata analysispattern formation
Output against the department
Publications88bottom 20% of dept.320th of 402
this lab
most publishedleast published
Citations5.1kbottom 29% of dept.286th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.