University of Virginia-Main Campus · NeuroscienceKuan Lab
Chia-Yi Kuan · Charlottesville, Virginia
Research Focus
Dr. Chia-Yi Kuan's lab focuses on understanding the causes and potential treatments for diseases that affect the brain, particularly Alzheimer's disease and neonatal brain injuries. The lab explores the role of specific proteins in neurotoxicity and cognitive impairment, as well as using advanced imaging techniques to monitor brain function in newborns with hypoxic-ischemic encephalopathy. Through their research, the lab aims to develop new therapeutic strategies to mitigate these serious health issues.
Alzheimer's diseaseneurotoxicityhyperphosphorylated tauneonatal hypoxia-ischemiacerebral metabolic rate of oxygenbrain imagingcognitive impairmenttherapeutic hypothermiaoxidative phosphorylationbiomarkers
Research Aims
5AIM 01Investigate the neurotoxic effects of hyperphosphorylated tau on neurons.
AIM 02Measure the cerebral metabolic rate of oxygen in neonatal brain injuries.
AIM 03Test the efficacy of pharmacological treatments in reducing tau-induced cognitive deficits.
AIM 04Explore the relationship between mitochondrial function and brain injury in hypoxia-ischemia.
AIM 05Assess the effectiveness of hypothermia in preventing brain damage after neonatal hypoxia.
Skills the Lab Values
in vivo mouse modelsintrahippocampal injectionsphotoacoustic microscopycell culturebiochemical assaysbehavioral testinghistology techniquesdata analysis using Pythonimmunofluorescencedrug treatment protocols
Output against the department
Publications39bottom 7% of dept.623rd of 671
this lab
most publishedleast published
Citations6.7kbottom 46% of dept.359th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.