University of California-Los Angeles · BiochemistryZhu Lab
Yazhen Zhu · Los Angeles, California
Research Focus
Dr. Yazhen Zhu's lab focuses on improving the early detection of hepatocellular carcinoma (HCC), a severe type of liver cancer. The team is developing a novel assay that uses advanced chemistry to isolate and quantify specific particles released by tumors, which could serve as better biomarkers. This approach aims to enhance the accuracy of current diagnostic methods, ultimately allowing for earlier and more successful interventions for patients at risk of HCC.
Hepatocellular CarcinomaExtracellular VesiclesClick ChemistryBiomarkersCancer DiagnosisImmuno-PCR
Research Aims
5AIM 01Develop a highly sensitive assay for detecting hepatocellular carcinoma-associated extracellular vesicles.
AIM 02Quantify various subpopulations of extracellular vesicles in patient plasma samples.
AIM 03Utilize click chemistry for efficient isolation of tumor-derived extracellular vesicles.
AIM 04Integrate multiple detection technologies to improve specificity and sensitivity in cancer diagnostics.
AIM 05Enhance early diagnosis of liver cancers to improve patient outcomes.
Skills the Lab Values
Cell CulturePCRProtein AnalysisImmunoassaysMicroscopyBioinformaticsReal-time Quantitative PCRSurface Plasmon ResonanceSignal Processing
Output against the department
Publications138bottom 39% of dept.243rd of 402
this lab
most publishedleast published
Citations8.0kbottom 43% of dept.230th of 402
this lab
most citedleast cited
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