UWMUniversity of Wisconsin-Madison · Chemistry
Protein Aggregation and Diabetes Unit
Martin T Zanni · Madison, Wisconsin
Research Focus
Dr. Martin T. Zanni's lab at the University of Wisconsin-Madison focuses on understanding how a protein called hIAPP forms aggregates that are linked to type 2 diabetes. They use advanced techniques to study the structure of these protein aggregates and their effects on pancreatic cells. By developing models that mimic these conditions, the lab aims to uncover new insights that could lead to better therapies for diabetes.
hIAPPamyloid aggregationtype 2 diabetestransgenic modelsprotein structure
Research Aims
3AIM 01Refine the structural model of hIAPP oligomers.
AIM 02Investigate a hereditary mutation linked to early onset diabetes.
AIM 03Test in vitro hypotheses using transgenic mouse models.
Skills the Lab Values
2D infrared spectroscopyNMR spectroscopyprotein purificationcell cultureanimal modeling
Output against the department
Publications468top 19% of dept.42nd of 216
this lab
most publishedleast published
Citations14ktop 37% of dept.79th of 216
this lab
most citedleast cited
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