Northwestern University · BiologyCardiac Inflammation Research Lab
Edward Benjamin Thorp · Evanston, Illinois
Research Focus
Dr. Edward Thorp's lab focuses on understanding how inflammation affects heart health, particularly in conditions like heart failure and ischemic injury. The lab investigates how different immune cells, specifically macrophages, interact with other heart cells to either worsen or alleviate inflammation. By exploring the underlying mechanisms and finding new pathways for intervention, the research aims to uncover potential treatments for heart diseases related to chronic inflammation.
inflammationheart failuremacrophagescardiac healthischemic injuryimmunometabolismcell signalingtherapeuticstissue repair
Research Aims
5AIM 01Investigate the role of macrophages in cardiac inflammation and heart failure.
AIM 02Examine how risk factors like hypertension affect macrophage signaling circuits.
AIM 03Identify novel pathways of communication between macrophages and progenitor cells.
AIM 04Explore new therapeutic candidates for resolving cardiac inflammation.
AIM 05Understand cellular mechanisms that contribute to tissue repair in the heart.
Skills the Lab Values
cell cultureanimal modelsPCRWestern blotflow cytometrymolecular biology techniquesimmunohistochemistrydata analysis in R or PythonCRISPR
Output against the department
Publications205top 32% of dept.329th of 1,033
this lab
most publishedleast published
Citations9.0ktop 42% of dept.438th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.