University of Washington-Seattle Campus · BiologyLatimer Proteotoxicity Lab
Caitlin Shannon Latimer · Seattle, Washington
Research Focus
Dr. Caitlin Shannon Latimer's lab at the University of Washington focuses on understanding the mechanisms underlying Alzheimer's disease, particularly how tau and TDP-43 proteins interact to worsen the condition. Using C. elegans as a model organism, her research aims to uncover the roles of specific genes and pathways that contribute to the severity of Alzheimer's when TDP-43 is also present. By combining molecular biology techniques with human brain tissue analysis, the lab seeks to identify potential targets for new treatments and diagnostic methods for Alzheimer's disease and related conditions.
Alzheimer's diseasetauTDP-43C. elegansproteotoxicitylysosomal autophagyneurodegenerationgene expressionspatial proteomics
Research Aims
3AIM 01Investigate the mechanistic pathways involved in tau and TDP-43 synergy using C. elegans models.
AIM 02Analyze gene expression changes related to lysosomal enzymes in combined tau and TDP-43 models.
AIM 03Measure protein and gene expression in human brain regions affected by pTDP-43 pathology.
Skills the Lab Values
C. elegans model organism studybulk RNA sequencingNanoString technologygene expression analysisprotein expression measurementautophagy pathway studyspatially preserved interrogation of tissuestransgenic animal techniques
Output against the department
Publications156top 43% of dept.443rd of 1,033
this lab
most publishedleast published
Citations3.5kbottom 26% of dept.764th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.