University of California-Los Angeles · PharmacologyThe Prostate Precision Lab
Johannes Czernin · Los Angeles, California
Research Focus
Dr. Johannes Czernin's lab at UCLA focuses on enhancing the effectiveness of treatments for advanced prostate cancer. The research primarily revolves around understanding how different genetic and immunological factors influence responses to a specific type of targeted therapy known as PSMA-RPT, which can improve survival rates but often falls short of optimal results. By analyzing tumor characteristics and immune interactions, the lab aims to develop new combination therapies that address treatment resistance and improve patient outcomes.
prostate cancerPSMA-RPTimmunotherapytumor microenvironmentTP53 mutational status
Research Aims
3AIM 01Identify signaling alterations induced by RPT in prostate cancer models.
AIM 02Investigate the impact of TP53 mutations on treatment response in mice.
AIM 03Develop combination therapies to enhance tumor immunogenicity and improve treatment efficacy.
Skills the Lab Values
tumor modelingdosimetry studiesphosphoproteomicscell cultureanimal models
Output against the department
Publications589top 8% of dept.35th of 462
this lab
most publishedleast published
Citations28ktop 11% of dept.51st of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.