Columbia University in the City of New York · BiochemistryHIV Replication Dynamics Lab
Hashim M Al-Hashimi · New York, New York
Research Focus
Dr. Hashim Al-Hashimi's lab at Columbia University focuses on understanding how HIV-1, the virus that causes AIDS, regulates its own replication through RNA structures. By studying the dynamics of RNA and its interactions with proteins, the lab aims to create models that predict how these processes work at a molecular level. This research could lead to new strategies for developing targeted therapies that impede the virus's ability to replicate.
HIV-1RNA dynamicsRNA-protein interactionstranscriptional activationbiophysical properties
Research Aims
3AIM 01Develop a suite of technologies to measure RNA-protein interactions quantitatively.
AIM 02Integrate NMR data with computational molecular dynamics to analyze RNA structures.
AIM 03Refine a thermodynamic model to predict transcriptional activity based on RNA conformations.
Skills the Lab Values
NMR spectroscopymolecular dynamics simulationsRNA sequencinghigh-throughput screeningthermodynamic modeling
Output against the department
Publications265top 26% of dept.105th of 402
this lab
most publishedleast published
Citations12ktop 42% of dept.168th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.