University of California-Los Angeles · NeuroscienceNeurogenetics and Stem Cell Unit
Daniel H Geschwind · Los Angeles, California
Research Focus
Dr. Daniel Geschwind's lab at UCLA focuses on understanding the genetics behind neuropsychiatric and neurodevelopmental disorders. The lab uses advanced stem cell technologies and high-throughput phenotyping to study how various genes affect brain development and function, aiming to uncover the biological mechanisms that contribute to disorder risk. To achieve this, they develop models using human stem cells to analyze gene knockouts and their effects on neuronal behavior.
neuropsychiatric disordersstem cell engineeringgene knockouthigh-throughput phenotypingbrain developmentmolecular analysisneural functionCRISPRRNA sequencing
Research Aims
5AIM 01Develop high-throughput systems to generate and study gene knockouts.
AIM 02Characterize the impact of neuropsychiatric disorder genes on neural cell function.
AIM 03Utilize stem cell models to assess brain development patterns.
AIM 04Perform quantitative analyses to uncover mechanistic insights into disorder risk.
AIM 05Facilitate data sharing and comparisons with other research groups.
Skills the Lab Values
stem cell culturegene editing (CRISPR)high-throughput screeningRNA sequencingautomated imagingoptical recording techniquesdata analysis3D cell culturemolecular phenotyping
Output against the department
Publications970top 4% of dept.24th of 671
this lab
most publishedleast published
Citations151ktop 1% of dept.7th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.