University of Pennsylvania · Biomedical EngineeringFacciabene Lab
Andrea Facciabene · Philadelphia, Pennsylvania
Research Focus
Dr. Andrea Facciabene leads innovative research at the University of Pennsylvania focusing on cancer treatment, specifically exploring the combination of radiation therapy with T-cell therapy and modifications of the gut microbiome. Their work seeks to enhance antitumor responses in patients with lymphomas and lung cancer, aiming to redefine treatment strategies to prolong patients' survival. By studying how gut bacteria can impact cancer therapies, the lab is at the forefront of novel cancer treatment research that could lead to groundbreaking advancements in oncology.
cancer treatmentradiation therapygut microbiomeT-cell therapylymphomaclinical trialsvancomycinimmune responsetumor antigens
Research Aims
5AIM 01Investigate the synergistic effects of combining radiation therapy with CART therapy and gut microbiome modulation.
AIM 02Evaluate the impact of vancomycin on gut microbiota and antitumor immune responses.
AIM 03Conduct clinical trials to test the efficacy of the combined therapy in patients with lymphoma.
AIM 04Characterize molecular changes in the immune system as a result of the therapy.
AIM 05Optimize treatment regimens including dose fractionation and treatment volume.
Skills the Lab Values
cell cultureclinical trial designanimal modelsgene expression analysismolecular characterizationflow cytometrydata collectionantigen presentation techniquesmetabolomics
Output against the department
Publications149bottom 32% of dept.400th of 595
this lab
most publishedleast published
Citations6.1kbottom 47% of dept.318th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.