Icahn School of Medicine at Mount Sinai · NeuroscienceThe Cognition Lab
George W. Huntley · New York, New York
Research Focus
Dr. George W. Huntley's lab focuses on understanding the early cognitive impairments that occur in individuals with Parkinson's disease, specifically how these changes relate to the neurobiology of the brain. The team investigates a mouse model carrying a mutation linked to Parkinson's, exploring the role of cholinergic signaling and how it differs between male and female mice. The goal is to identify potential treatments for cognitive decline in Parkinson's patients and improve diagnosis tools.
Parkinson's diseasecognitive impairmentcholinergic signalingneurobiologydementiamouse modelsprefrontal cortexsex differencesLRRK2 gene mutation
Research Aims
5AIM 01Investigate the underlying neurobiology of cognitive deficits in Parkinson's disease.
AIM 02Characterize cholinergic innervation in the prefrontal cortex across different sexes.
AIM 03Examine the effects of ACh signaling on cognitive performance in mice.
AIM 04Develop potential therapeutic strategies for enhancing cognitive function in Parkinson's patients.
AIM 05Define sex-specific differences in cognitive decline associated with LRRK2 mutations.
Skills the Lab Values
mouse modelsbehavioral testingelectrophysiologyoptogeneticsfluorescent biosensorsimmunohistochemistrydata analysisPCRWestern blot
Output against the department
Publications107bottom 37% of dept.425th of 671
this lab
most publishedleast published
Citations10ktop 39% of dept.263rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.