Yale University · NeuroscienceRangaraju Lab
Srikant Rangaraju · New Haven, Connecticut
Research Focus
Dr. Srikant Rangaraju's lab at Yale University focuses on understanding the role of microglia, the brain's immune cells, in Alzheimer's disease (AD). By studying the proteins produced by these cells, the lab aims to uncover how neuroinflammation contributes to AD pathology and develop new biomarkers that can aid in diagnosis and treatment. They utilize innovative techniques like ciBONCAT to analyze protein changes in living models, providing fresh perspectives on this complex disease.
neuroinflammationAlzheimer's diseaseproteomicsbiomarkersmicrogliaciBONCATamyloid betaAPOE4cerebrospinal fluidtransgenic models
Research Aims
3AIM 01Define microglia-specific protein alterations in Alzheimer's disease using ciBONCAT.
AIM 02Determine how human APOE4 and APOE3 expression affects microglial protein changes in amyloid beta pathology.
AIM 03Identify novel biomarkers of neuroinflammation in cerebrospinal fluid from mouse models of Alzheimer's disease.
Skills the Lab Values
mass spectrometryin-vivo proteomic labelingknock-in mouse modelscerebrospinal fluid analysisquantitative proteomicscell culture techniquesbioinformaticsdata interpretationprotein isolation methodsanimal handling
Output against the department
Publications252top 29% of dept.194th of 671
this lab
most publishedleast published
Citations8.0ktop 47% of dept.315th of 671
this lab
most citedleast cited
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