University of California-San Francisco · BiologyRoose Immunology Lab
Jeroen Roose · San Francisco, California
Research Focus
Dr. Jeroen Roose's lab at UCSF focuses on understanding how T cell receptors (TCR) signal within the immune system. They study the unique mechanisms by which T cells can differentiate between self and non-self, ensuring appropriate immune responses. The lab employs a range of techniques from structural biology to computational biology to explore how TCR signaling pathways are organized and regulated.
T cell receptorsignal transductionimmunologyproteomicscell signalingbiophysicstyrosine phosphorylationcell activationadaptive immunity
Research Aims
4AIM 01Identify the unique kinases utilized in TCR signaling.
AIM 02Characterize the circuitry that distinguishes self from non-self recognition.
AIM 03Investigate how LAT condensation regulates signaling events.
AIM 04Explore how TCR signaling influences Ras GEF regulation.
Skills the Lab Values
protein purificationcell cultureimmunofluorescence microscopyflow cytometrymass spectrometryWestern blotcomputational modelingCRISPRRNA interference
Output against the department
Publications129bottom 46% of dept.553rd of 1,033
this lab
most publishedleast published
Citations8.6ktop 44% of dept.455th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.