Virginia Polytechnic Institute and State University · ChemistrySantos Fibrosis Lab
Webster L Santos · Blacksburg, Virginia
Research Focus
Dr. Webster L Santos' lab at Virginia Tech focuses on developing new therapies for chronic kidney disease (CKD), particularly aimed at reducing kidney fibrosis, a major complication of CKD. They investigate the role of sphingosine-1-phosphate (S1P) signaling in kidney health and aim to improve the design of inhibitors that can both halt and potentially reverse kidney damage. The ultimate goal is to create effective drugs for CKD that could lead to better patient outcomes and lower healthcare costs.
chronic kidney diseaserenal fibrosissphingosine-1-phosphatedrug developmentinflammation
Research Aims
3AIM 01Develop orally available SphK2 inhibitors to reduce renal fibrosis.
AIM 02Enhance the potency and selectivity of Spns2 inhibitors.
AIM 03Test the efficacy of combined SphK2 and Spns2 inhibition in various animal models.
Skills the Lab Values
organic synthesisanimal modelingin vivo pharmacologydrug formulationcell culturebiochemical assays
Output against the department
Publications205top 50% of dept.109th of 216
this lab
most publishedleast published
Citations5.2kbottom 38% of dept.135th of 216
this lab
most citedleast cited
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