Thomas Jefferson University · PharmacologyProstate Cancer Resistance Research Unit
Marja T Nevalainen · Philadelphia, Pennsylvania
Research Focus
Dr. Marja T Nevalainen's lab focuses on understanding and overcoming treatment resistance in advanced prostate cancer. The research specifically investigates how the Jak2 signaling pathway contributes to the persistent expression of androgen receptors in prostate cancer cells, which leads to disease progression despite existing therapies. By targeting Jak2 with new inhibitors, the lab aims to develop more effective treatments for patients with castrate-resistant prostate cancer.
androgen receptorprostate cancerJak2drug resistancetherapeutics
Research Aims
3AIM 01Identify mechanisms controlling androgen receptor mRNA expression by Jak2 signaling.
AIM 02Evaluate the effectiveness of Jak2 inhibitors in reducing androgen receptor levels in prostate cancer.
AIM 03Investigate the impact of Jak2 inhibition on the progression of castrate-resistant prostate cancer.
Skills the Lab Values
cell culturemouse modelsPCRWestern blotRNA sequencingdrug screeningxenograft procedureschromatin immunoprecipitationbioinformaticssignal transduction analysis
Output against the department
Publications176bottom 48% of dept.240th of 462
this lab
most publishedleast published
Citations4.8kbottom 36% of dept.297th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.