Stanford University · PharmacologyCimprich Lab
Karlene A Cimprich · Stanford, California
Research Focus
Dr. Karlene Cimprich's lab focuses on understanding how cells respond to DNA damage, particularly when DNA replication is stressed due to environmental factors. Their research investigates a protein called HLTF, which plays a crucial role in repairing stalled DNA replication and preventing mutations that could lead to cancer. The lab combines advanced techniques in molecular biology and biochemistry to uncover the mechanisms that protect the genome and cellular health under stress, ultimately contributing to insights into cancer therapy.
DNA damage responsereplication stressgenome stabilitycancer biologyHLTFDNA repairgenotoxic stressreplication forkmutagenesisproteomics
Research Aims
4AIM 01Investigate the domains of HLTF needed for its function in fork reversal and replication stress response.
AIM 02Characterize the mechanisms by which HLTF stabilizes replication forks during cellular stress.
AIM 03Determine the impact of HLTF loss on genome stability and cell proliferation under stress conditions.
AIM 04Explore the roles of other translocases in the replication stress response over time.
Skills the Lab Values
molecular cloningPCRcell culturebiochemical assayssingle-molecule imagingproteomicsXenopus oocyte manipulationDNA fiber assaygenomic analysesWestern blot
Output against the department
Publications102bottom 26% of dept.341st of 462
this lab
most publishedleast published
Citations18ktop 21% of dept.95th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.