University of Chicago · Microbiology & ImmunologyThe TB ImmunoLab
Shabaana A. Khader · Chicago, Illinois
Research Focus
Dr. Shabaana A. Khader's lab at the University of Chicago is focused on developing innovative vaccines against tuberculosis (TB). They study how certain immune responses can be enhanced to provide better protection against TB. The lab uses novel adjuvants to boost the immune system's Th1 and Th17 responses, aiming to create more effective vaccines that can tackle both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis.
tuberculosisvaccine developmentTh1 responseTh17 responseadjuvantsimmune responsesMycobacterium tuberculosisinfectious diseases
Research Aims
5AIM 01Develop novel adjuvanted vaccines that induce Th1 and Th17 immune responses against TB.
AIM 02Identify optimal antigen and prime-boost strategies for enhanced vaccine efficacy.
AIM 03Evaluate the safety and immunogenicity of vaccine candidates in animal models.
AIM 04Investigate the mechanisms by which immune adjuvants enhance protective responses.
AIM 05Target drug-resistant strains of Mycobacterium tuberculosis with innovative vaccine strategies.
Skills the Lab Values
vaccine formulationcell culturemouse modelsimmunological assayscytokine profilingPCRflow cytometrydendritic cell therapyWestern blotaerosol challenge models
Output against the department
Publications265top 21% of dept.100th of 486
this lab
most publishedleast published
Citations16ktop 23% of dept.113th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.