University of Virginia-Main Campus · PharmacologyBayliss Neurobiology Lab
Douglas A. Bayliss · Charlottesville, Virginia
Research Focus
Dr. Douglas A. Bayliss leads a research lab at the University of Virginia focusing on how specific neurons in the brainstem regulate breathing and arousal responses to carbon dioxide levels in the body. His work has implications for understanding disorders like congenital central hypoventilation syndrome (CCHS) and sudden infant death syndrome (SIDS), which are linked to dysfunction in these neuronal pathways. The lab studies the molecular mechanisms and cellular functions of these neurons to gain insights into their role in respiratory health.
CO2 sensingneuron physiologyrespiratory regulationPhox2barousal circuitschemosensitivityCCHSbrainstem neuronstranscriptional regulation
Research Aims
4AIM 01Investigate the gene regulatory functions of the Phox2b transcription factor in RTN neurons.
AIM 02Characterize how Phox2b mutations affect CO2 and H+ sensing in respiratory neurons.
AIM 03Examine the connectivity and molecular phenotype of RTN neurons with their brainstem targets.
AIM 04Assess the mechanisms of neuroadaptive changes in RTN neurons under chronic physiological challenges.
Skills the Lab Values
gene manipulationviral vector techniquessingle-cell RNA sequencingmouse modelsplethysmographyin vitro electrophysiologyphotometrytrans-synaptic tracingimmunohistochemistry
Output against the department
Publications263top 31% of dept.141st of 462
this lab
most publishedleast published
Citations19ktop 19% of dept.86th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.