Washington University in St Louis · Biomedical EngineeringGoyal Lab
Manu S Goyal · Saint Louis, Missouri
Research Focus
Dr. Manu Goyal's lab focuses on understanding the metabolic dysfunctions associated with Alzheimer's disease using advanced imaging techniques. By examining how amyloid plaques impact brain metabolism at both the cellular and network levels, the lab aims to unravel the connections between these metabolic changes and the progression of dementia. Ultimately, the research seeks to determine if treatments targeting amyloid can reverse these dysfunctions, paving the way for improved therapies for Alzheimer’s patients.
Alzheimer's Diseasemetabolic dysfunctionamyloid plaquesimaging techniquesbrain metabolism
Research Aims
3AIM 01Explore the relationship between amyloid plaques and cellular metabolism in Alzheimer's mice
AIM 02Assess the impact of metabolic dysfunction on overall brain metabolism and organization
AIM 03Investigation of the reversibility of metabolic issues following amyloid clearance
Skills the Lab Values
two-photon fluorescence lifetime imaging microscopy (TP-FLIM)photoacoustic microscopy (PAM)wide-field optical imaging (WFOI)cell culturein vivo imaging
Output against the department
Publications230top 45% of dept.265th of 595
this lab
most publishedleast published
Citations4.6kbottom 35% of dept.387th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.