University of Pennsylvania · Biomedical EngineeringOsteoarthritis Treatment and Innovation Lab
Zhiliang Cheng · Philadelphia, Pennsylvania
Research Focus
Dr. Zhiliang Cheng's lab at the University of Pennsylvania focuses on developing innovative treatments for osteoarthritis (OA), which is a debilitating joint disease. The lab aims to create dual-action nanoparticles that can effectively deliver therapies to restore cartilage health and reduce joint pain. By using both in vitro and animal models, the research aims to provide solutions that may improve the quality of life for those affected by OA and other degenerative joint diseases.
nanoparticlesosteoarthritisdrug deliverytissue engineeringjoint healthbiocompatible materialscombination therapy
Research Aims
5AIM 01Develop dual-action nanoparticles for osteoarthritis treatment
AIM 02Evaluate the effectiveness of the nanoparticles in mouse models
AIM 03Characterize the physical-chemical properties of the nanoparticles
AIM 04Assess treatment impact on cartilage integrity
AIM 05Establish a basis for future clinical trials in OA patients.
Skills the Lab Values
nanoparticle synthesismicroscopyin vivo animal modelsdrug formulationpolymer characterizationMRI techniquesbiological assayscell cultureoxidative stress analysisprotein signaling analysis
Output against the department
Publications103bottom 18% of dept.486th of 595
this lab
most publishedleast published
Citations5.7kbottom 44% of dept.333rd of 595
this lab
most citedleast cited
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