Baylor College of Medicine · BiologyReproductive Health Innovations Lab
Martin M. Matzuk · Houston, Texas
Research Focus
Dr. Martin M. Matzuk's lab at Baylor College of Medicine focuses on innovative areas of reproductive biology, particularly in developing new male contraceptives and therapeutic options for conditions like endometriosis. The lab uses advanced drug discovery techniques to target specific proteins called kinases, which play crucial roles in fertility and reproductive health. By exploring these biological processes, the lab aims to create effective non-hormonal contraceptives and medications that improve women's health outcomes, especially for those suffering from endometriosis.
male contraceptionserine/threonine kinasesendometriosisdrug discoveryreproductive biologykinase inhibitorsnon-hormonal contraceptivestestis biology
Research Aims
5AIM 01Develop non-hormonal contraceptives by targeting serine/threonine kinase 33.
AIM 02Identify and validate therapeutic kinases involved in endometriosis.
AIM 03Screen for novel kinase inhibitors using DEC-Tec technology.
AIM 04Evaluate the metabolic and pharmacokinetic properties of kinase inhibitors in animal models.
AIM 05Create optimized lead compounds suitable for clinical testing.
Skills the Lab Values
DNA-Encoded Chemistry Technology (DEC-Tec)medicinal chemistryX-ray crystallographyin vivo studiescell culturesiRNA knockdown techniquespharmacokinetics analysisdrug stability studies
Output against the department
Publications575top 5% of dept.52nd of 1,033
this lab
most publishedleast published
Citations56ktop 4% of dept.41st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.