Tufts University · Microbiology & ImmunologyIacomini Lab
John J Iacomini · Medford, Massachusetts
Research Focus
Dr. John J. Iacomini's lab at Tufts University focuses on understanding how microRNAs regulate gene expression and influence kidney transplant rejection. By studying these small RNA molecules, the lab aims to uncover the mechanisms behind chronic antibody-mediated rejection, which is a leading cause of transplant failure. Their research involves a combination of advanced techniques to map interactions between microRNAs and their target mRNAs, providing insights that could improve the success rates of kidney transplants.
microRNAskidney transplantationgene regulationAntibody-mediated rejectionpost-transcriptional regulationRNA-Binding Proteinsrenal injury
Research Aims
5AIM 01Investigate the role of microRNAs in regulating gene expression during kidney transplant rejection.
AIM 02Map the interactions between microRNAs and their target mRNAs in relation to renal injury.
AIM 03Analyze the clinical relevance of findings by comparing changes in human kidney transplant patients.
AIM 04Identify gene pathways influenced by microRNAs to improve understanding of antibody-mediated rejection.
AIM 05Develop a resource for the transplantation community based on miRNA-mRNA interaction maps.
Skills the Lab Values
RNA extractionmicroRNA profilingmRNA isolationflow cytometrymurine modelspathway analysisRT-qPCR (reverse transcription quantitative PCR)cross-linking experimentsdata analysis using bioinformatics tools
Output against the department
Publications103bottom 37% of dept.305th of 486
this lab
most publishedleast published
Citations8.4ktop 43% of dept.209th of 486
this lab
most citedleast cited
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