Yale University · Microbiology & ImmunologyMucosal Immunity and Vaccine Development Lab
David R. Martinez · New Haven, Connecticut
Research Focus
David R. Martinez's lab at Yale University is focused on developing innovative mucosal vaccines aimed at providing robust and long-lasting protection against respiratory viruses, particularly coronaviruses. The lab studies how specific adjuvants can enhance the immune response in the respiratory tract, looking to elicit protective IgA antibodies that can prevent the spread of infections. Through various experimental models, the lab aims to improve vaccination strategies to combat current and future viral threats.
mucosal vaccinesIgASARS-CoV-2nanoparticle vaccineadjuvantsZoonotic coronavirusesrespiratory immunityimmune signalingmemory B cells
Research Aims
3AIM 01Test how mast cells and antigen-presenting cells influence the production of durable IgA through specific cytokines.
AIM 02Determine how intranasal boosting impacts the development of IgA-secreting plasma cells and memory B cells in the respiratory tract.
AIM 03Investigate if the nanoparticle vaccine can prevent the transmission of SARS-CoV-2 variants in animal models.
Skills the Lab Values
intranasal vaccinationanimal modelsimmunophenotypinglineage tracinggene expression analysisfluorescent reporter techniquesvaccine safety testingcytokine analysisimmunology techniques
Output against the department
Publications168top 39% of dept.191st of 486
this lab
most publishedleast published
Citations18ktop 20% of dept.99th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.