SLUSaint Louis University · Pharmacology
Salvemini Lab
Daniela Salvemini · Saint Louis, Missouri
Research Focus
Dr. Daniela Salvemini's lab focuses on understanding how chemotherapy can impair cognition, a condition known as chemotherapy-induced cognitive impairment (chemobrain). The research investigates how molecules in the brain, particularly sphingosine-1-phosphate receptors, contribute to cognitive decline after chemotherapy. The goal is to find potential treatments that could lessen this side effect for cancer survivors.
chemobrainsphingosine-1-phosphateneuroinflammationmitochondrial dysfunctiondrug repurposingcognitive impairmentTLR4palliative carechemo-related side effects
Research Aims
4AIM 01Explore the role of sphingosine-1-phosphate receptors in chemotherapy-induced cognitive impairment.
AIM 02Investigate how TLR4 mediates sphingolipid metabolism during cognitive decline after chemotherapy.
AIM 03Assess the effects of S1PR1 antagonists on mitochondrial function and inflammation in the brain.
AIM 04Evaluate the safety and efficacy of existing FDA-approved drugs in preventing cognitive impairment related to chemotherapy.
Skills the Lab Values
cell culturemouse modelsRNA extractionWestern blotimmunohistochemistrybehavioral assaysbiochemical assaysgenetic manipulationpharmacological evaluation
Output against the department
Publications185top 48% of dept.220th of 462
this lab
most publishedleast published
Citations9.3ktop 41% of dept.189th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.