Dartmouth College · Microbiology & ImmunologyMononuclear Phagocyte Research Unit
Claudia V Jakubzick · Hanover, New Hampshire
Research Focus
Dr. Claudia V Jakubzick leads a research lab at Dartmouth College that focuses on understanding the role of mononuclear phagocytes in the immune system. Her lab compares the function and gene expression of these immune cells in both humans and mice to identify their similarities and differences. This work aims to improve our understanding of how these cells respond to infections and how this knowledge can be applied to develop better treatments for diseases.
mononuclear phagocytesRNA sequencingcross-species homologyimmune responsegene expression profiling
Research Aims
4AIM 01Investigate the gene expression and functions of mononuclear phagocytes in humans and mice.
AIM 02Identify conserved and unique genetic markers for different subtypes of mononuclear phagocytes.
AIM 03Perform functional validation of key genes using in vivo and in vitro models.
AIM 04Characterize cross-species homologies in immune responses of mononuclear phagocytes.
Skills the Lab Values
bulk RNA sequencingsingle-cell RNA sequencingbioinformaticsmurine modelscellular microscopy
Output against the department
Publications121bottom 46% of dept.261st of 486
this lab
most publishedleast published
Citations16ktop 24% of dept.118th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.