University of Michigan-Ann Arbor · BiochemistryThe Caries Combat Lab
Randy B. Stockbridge · Ann Arbor, Michigan
Research Focus
The lab led by Dr. Randy B. Stockbridge focuses on developing innovative treatments to combat early childhood caries (ECC), a significant dental health issue affecting millions of children globally. By studying how certain harmful oral microbes manage to resist fluoride treatment, the lab aims to create specialized fluoride efflux inhibitors that can enhance the effectiveness of fluoride therapies. The ultimate goal is to personalize dental treatments, making them more effective in reversing the dysbiosis associated with ECC.
fluoridedental cariesoral microbiomeantimicrobial agentspersonalized medicine
Research Aims
5AIM 01Develop fluoride efflux inhibitors for specific dental pathogens.
AIM 02Explore the mechanisms by which microorganisms expel fluoride.
AIM 03Tailor fluoride-based therapies to individual oral dysbiosis profiles.
AIM 04Assess the impact of fluoride inhibitors on complex dental biofilms.
AIM 05Create treatment strategies that maximize the antimicrobial effects of fluoride.
Skills the Lab Values
fluoride efflux assaymicrobial biofilm analysisstructural biology techniquesdata modelingoral microbiome profiling
Output against the department
Publications166bottom 48% of dept.211th of 402
this lab
most publishedleast published
Citations2.3kbottom 8% of dept.368th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.