Vanderbilt University · PhysiologyLi Lab
Bingshan Li · Nashville, Tennessee
Research Focus
Bingshan Li's lab at Vanderbilt University focuses on understanding how different types of brain cells communicate and interact during the progression of Alzheimer's disease (AD). By employing advanced computational techniques and human-derived brain models, the lab aims to uncover the complex cellular mechanisms that contribute to memory loss and cognitive decline in AD patients. This research provides insights that could help in developing new therapeutic strategies for this devastating disorder.
Alzheimer's diseasecell-cell communicationmicrogliaastrocytesneurodegenerationcognitive functionhuman iPSCcortical organoidssingle-cell analysisdisease progression
Research Aims
3AIM 01Develop novel analytic approaches for cell-cell communication in Alzheimer's disease.
AIM 02Analyze single-cell -omics data to identify communication networks linked to AD pathology.
AIM 03Validate candidate cell-cell communications using human iPSC-derived cortical organoids.
Skills the Lab Values
Pythonstatistical modelingsingle-cell RNA sequencingcell culturehuman iPSC technologybioinformaticsdata analysisnetwork-based modelingorganoid cultureimmunostaining
Output against the department
Publications229top 26% of dept.75th of 286
this lab
most publishedleast published
Citations32ktop 6% of dept.18th of 286
this lab
most citedleast cited
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