University of Virginia-Main Campus · BiologyNeural Stem Cell Development Lab
Noelle D Dwyer · Charlottesville, Virginia
Research Focus
Dr. Noelle D Dwyer's lab at the University of Virginia focuses on understanding how neural stem cells develop into the brain and how disruptions in this process can lead to neurodevelopmental disorders. They utilize mouse genetics to study lethal mutations that affect brain development and other related organs. The team's research combines various phenotyping techniques to analyze these mutations, providing insights into the cellular mechanisms underlying brain malformations and developmental disorders.
neural stem cellsbrain developmentmutant miceneurodevelopmental disorderscytokinesisphenotypinggeneticshistopathologydevelopmental biology
Research Aims
5AIM 01Investigate the genes and processes involved in brain development using IMPC mutant mice.
AIM 02Characterize developmental defects in lethal knockout lines.
AIM 03Perform gross phenotyping and histopathology on selected mutants.
AIM 04Analyze cytokinesis defects in neural stem cells to understand brain malformations.
AIM 05Share data with the broader research community to enhance knowledge on neurodevelopmental disorders.
Skills the Lab Values
mouse modelsphenotype analysisPCRhistopathologycell culturestatistical analysisgenetic manipulationimaging techniquesdata sharing
Output against the department
Publications39bottom 7% of dept.957th of 1,033
this lab
most publishedleast published
Citations3.7kbottom 29% of dept.738th of 1,033
this lab
most citedleast cited
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