UMCUniversity of Massachusetts Chan Medical School · Biology
Liver-Brain Health Research Lab
Jason K Kim · Worcester, Massachusetts
Research Focus
Dr. Jason K. Kim's lab focuses on understanding how insulin resistance and inflammation in the liver are linked to Alzheimer's disease. They research the roles of immune cells and inflammatory signals on brain health, exploring how these factors influence cognitive decline in aging individuals. Their findings aim to uncover potential new treatments for Alzheimer's and related neurodegenerative diseases.
Alzheimer's Diseaseinsulin resistanceinflammationmetabolic dysfunctionmacrophagescytokinesneurodegenerationliver-brain connectionagingdementia
Research Aims
4AIM 01Investigate age-related changes in metabolism and inflammation in peripheral organs during neuodegeneration.
AIM 02Define the role of liver macrophages in Alzheimer's pathology through cytokine manipulation.
AIM 03Establish connections between liver inflammation, insulin resistance, and brain health.
AIM 04Explore potential therapeutic targets related to liver immunity and metabolism for Alzheimer's disease.
Skills the Lab Values
PCRcell culturemouse modelsspatial transcriptomicshyperinsulinemic-euglycemic clampWestern blotmetabolomicsRNA sequencingimmunohistochemistrybiochemical assays
Output against the department
Publications263top 23% of dept.234th of 1,033
this lab
most publishedleast published
Citations32ktop 10% of dept.102nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.