Brown University · Microbiology & ImmunologyBrossay Immunology Lab
Laurent Brossay · Providence, Rhode Island
Research Focus
Dr. Laurent Brossay's lab at Brown University focuses on understanding how the immune system responds to viral infections, particularly murine cytomegalovirus (MCMV), which shares similarities with the human version. They investigate how Natural Killer (NK) cells behave in salivary glands during infection, revealing how these cells can limit immune responses without harming tissue. The lab aims to uncover the mechanisms behind viral persistence and the delicate balance between fighting infections and preventing damage to the host.
cytomegalovirusnatural killer cellsimmune systemviral persistencesalivary glands
Research Aims
3AIM 01Investigate the regulation of pathogen clearance and immunopathology.
AIM 02Study the mechanisms of MCMV persistence in salivary glands.
AIM 03Examine how NK cells limit T cell accumulation in the salivary glands.
Skills the Lab Values
mouse modelscell cultureimmunological assaysflow cytometryRNA sequencing
Output against the department
Publications132top 49% of dept.237th of 486
this lab
most publishedleast published
Citations7.8ktop 45% of dept.221st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.