University of Michigan-Ann Arbor · PhysiologySamuelson Regeneration Lab
Linda C. Samuelson · Ann Arbor, Michigan
Research Focus
Dr. Linda C. Samuelson's lab at the University of Michigan focuses on understanding how certain signaling pathways regulate gastric epithelial cells. Their research investigates the role of Wnt and retinoic acid in maintaining the stomach lining and how these pathways help repair tissue after injury. By studying these processes in both mouse models and human organoids, the lab aims to develop insights that could lead to new treatments for gastric diseases that involve cell overgrowth or damage.
Wnt signalingretinoic acidgastric stem cellsepithelial cell regenerationgastrointestinal health
Research Aims
5AIM 01Define the role of Wnt signaling in gastric epithelial cell homeostasis.
AIM 02Investigate the impact of retinoic acid signaling on chief cell differentiation.
AIM 03Explore the regenerative response of gastric epithelial cells after injury.
AIM 04Analyze cellular changes through RNA sequencing techniques.
AIM 05Develop insights into strategies for gastric disease therapies.
Skills the Lab Values
mouse modelsorganoid culturebulk RNA sequencingsingle-cell RNA sequencinghistological analysislineage tracing
Output against the department
Publications245top 22% of dept.64th of 286
this lab
most publishedleast published
Citations8.6ktop 39% of dept.112th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.