WMCWeill Medical College of Cornell University · Biochemistry
The GPCR Nexus
Joshua Levitz · New York, New York
Research Focus
Dr. Joshua Levitz's lab focuses on understanding how certain proteins and receptors in the brain regulate neuronal signaling, particularly through G protein-coupled receptors (GPCRs). His research explores the interactions between different types of receptors and their accessory proteins, which play critical roles in brain function and can influence neurological and psychiatric disorders. By employing advanced techniques like microscopy and electrophysiology, the lab aims to elucidate the molecular mechanisms by which these receptors operate and their implications for treating various mental health conditions.
GPCRneurotransmissionneurotrophinssynaptic plasticityneuromodulatorselectrophysiologyneuropsychiatric disordersstructural biologybiophysics
Research Aims
3AIM 01Investigate KCTD regulation of GABAB receptor coupling at the molecular level.
AIM 02Examine the cellular mechanisms by which KCTDs modulate neuronal GPCR signaling.
AIM 03Characterize the interaction between neurotrophin receptors and metabotropic glutamate receptors to understand synaptic plasticity.
Skills the Lab Values
cryo-electron microscopyelectrophysiologycell culturefluorescence microscopyproximity labelingmass spectrometrylive cell imagingbiophysical assaysprotein purification
Output against the department
Publications115bottom 30% of dept.282nd of 402
this lab
most publishedleast published
Citations4.3kbottom 24% of dept.305th of 402
this lab
most citedleast cited
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