University of California-San Francisco · Biomedical EngineeringFaddegon Lab
Bruce Faddegon · San Francisco, California
Research Focus
Dr. Bruce Faddegon's lab at UCSF focuses on improving cancer treatment techniques using particle therapy, which includes protons and carbon ions. They aim to develop more precise treatment planning methods based on a detailed understanding of ionization patterns produced by these therapies. By integrating new prediction models, the lab hopes to enhance the effectiveness of radiation therapy while minimizing damage to healthy tissue, ultimately improving outcomes for cancer patients.
particle therapyion therapylinear energy transferrelative biological effectivenesscancer treatmentpredictive modelingradiation oncologyionization patterns
Research Aims
4AIM 01Develop a predictive model based on ionization detail for high-LET radiation.
AIM 02Test the model using in vitro and in vivo systems to determine biological effects.
AIM 03Integrate ionization detail into clinical treatment planning for improved outcomes.
AIM 04Evaluate the effectiveness of this approach in treating prostate and chordoma cancer.
Skills the Lab Values
treatment planningbiological modelingdata analysisin vitro cell culturein vivo mouse modelscomputational algorithmsGPU-based computingMonte Carlo simulationsclinical trial evaluation
Output against the department
Publications225top 46% of dept.272nd of 595
this lab
most publishedleast published
Citations7.5ktop 46% of dept.274th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.