University of Florida · BiochemistryPhinney Stem Cell Lab
Donald G Phinney · Gainesville, Florida
Research Focus
Dr. Donald G. Phinney's lab focuses on improving the therapeutic applications of mesenchymal stem cells (MSCs) for various human diseases. By developing a Clinical Indications Prediction (CLIP) scale, the lab aims to enhance the understanding of how donor characteristics and manufacturing processes affect the potency of MSCs. This research is crucial in creating tailored MSC therapies that yield better patient outcomes.
mesenchymal stem cellsCLIP scaledonor selectiontherapeutic efficacybiomarkers
Research Aims
3AIM 01Develop the CLIP scale to predict donor differences in MSC potency.
AIM 02Investigate the epigenetic mechanisms behind TWIST1 variability among donors.
AIM 03Assess the impact of manufacturing processes on MSC potency pre- and post-production.
Skills the Lab Values
cell culturelarge-scale cell expansionRNA sequencingepigenetic analysisextracellular vesicle isolationflow cytometrycytokine assaysgene editingclinical trial design
Output against the department
Publications168bottom 48% of dept.208th of 402
this lab
most publishedleast published
Citations33ktop 10% of dept.39th of 402
this lab
most citedleast cited
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