Vanderbilt University · BiologyThe Microtubule Nexus
Irina Kaverina · Nashville, Tennessee
Research Focus
Dr. Irina Kaverina's lab focuses on understanding how the structural components of cells, specifically microtubules and their associated motor proteins, influence the function of insulin-producing beta cells. Through their research, the lab aims to uncover mechanisms that regulate insulin secretion, which is critical in managing blood sugar levels and preventing conditions like diabetes. By using advanced microscopy and modeling techniques, the lab investigates how these cellular components can be manipulated to improve beta cell function and glucose homeostasis.
microtubulesinsulin secretionbeta cellsmotor proteinsdiabetescell physiologyglucose homeostasiscytoskeletonmolecular motors
Research Aims
3AIM 01Investigate the roles of molecular motors in organizing microtubules for insulin granule delivery.
AIM 02Examine how kinesin proteins transport insulin granules along microtubules.
AIM 03Explore the function of dynein in directing insulin granule movement during secretion.
Skills the Lab Values
microscopymolecular modelingcell culturemouse modelsimmunofluorescence stainingprotein assaysimage analysisRNA isolationWestern blotgene expression analysis
Output against the department
Publications170top 39% of dept.402nd of 1,033
this lab
most publishedleast published
Citations7.8ktop 48% of dept.494th of 1,033
this lab
most citedleast cited
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