University of California-Irvine · PhysiologyLawson Immunology Lab
Devon A. Lawson · Irvine, California
Research Focus
Devon A. Lawson's lab at the University of California-Irvine focuses on understanding the role of immune cells in brain metastasis, particularly in breast cancer. The lab investigates how brain resident macrophages called microglia can affect tumor growth and immune responses within the central nervous system. Their research aims to uncover mechanisms that could lead to new immunotherapeutic strategies for treating metastatic breast cancer patients.
brain metastasismicrogliaimmunotherapybreast cancerT cell responseantigen presentationCNS diseasesimmune microenvironment
Research Aims
3AIM 01Investigate how microglia promote the T cell response in brain metastasis.
AIM 02Determine the role of regulatory T cells in disease progression despite an immune response.
AIM 03Examine the mechanisms of initial microglia activation in response to brain metastasis.
Skills the Lab Values
cell culturemouse modelsin vitro assaysflow cytometryWestern blotmolecular biology techniqueschemotaxis assaysimmune profilingimmunohistochemistry
Output against the department
Publications110bottom 33% of dept.191st of 286
this lab
most publishedleast published
Citations7.2ktop 46% of dept.132nd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.