University of California-Berkeley · NeuroscienceJagust Lab
William J. Jagust · Berkeley, California
Research Focus
Dr. William J. Jagust's lab focuses on understanding how the blood-brain barrier (BBB) and Alzheimer's disease (AD) pathology are connected. The research investigates how changes in the BBB function can lead to cognitive decline and AD, aiming to clarify the sequence of events that trigger the disease. By combining advanced imaging techniques in humans with experiments in mouse models, the lab seeks to unravel the mechanisms linking BBB disruption with protein deposits related to AD.
blood-brain barrierAlzheimer's Diseasecognitive declineamyloidtauneurovascularPET scanningDCE-MRImouse modelslongitudinal studies
Research Aims
5AIM 01Investigate the relationship between blood-brain barrier dysfunction and Alzheimer's disease pathology.
AIM 02Examine how BBB disruption influences amyloid and tau protein accumulation.
AIM 03Determine the effects of aging on BBB integrity and cognitive function.
AIM 04Use transgenic mouse models to explore the mechanisms of AD progression.
AIM 05Translate findings from lab models to human studies of cognitive health.
Skills the Lab Values
PET scanningDCE-MRIcell culturetransgenic mouse modelsimmunohistochemistrylongitudinal data analysisbiological modelingneurophysiology techniquesdata visualizationmolecular biology techniques
Output against the department
Publications1,005top 3% of dept.21st of 671
this lab
most publishedleast published
Citations120ktop 1% of dept.10th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.