University of California-Los Angeles · NeuroscienceBrain Organoid Research Lab
Bennett G Novitch · Los Angeles, California
Research Focus
Dr. Bennett Novitch's lab at UCLA focuses on understanding human brain development and disorders using advanced models called brain organoids. These organoids are engineered from human stem cells to mimic brain structures, allowing researchers to study how genetic mutations and environmental factors impact brain function. By examining the neural networks within these organoids, the lab aims to uncover the underlying mechanisms of neurodevelopmental disorders like Rett syndrome and explore potential treatments.
brain organoidsneurodevelopmental disordersRett syndromeneural networksstem cellsneurological diseaseelectrophysiologycalcium imaging
Research Aims
3AIM 01Investigate the relationship between genetic mutations and neural network dysfunction in Rett syndrome organoids.
AIM 02Explore the role of cellular mosaicism in MECP2 function on neural network activity.
AIM 03Determine whether organoid models of neurological diseases with seizures share distinct or common network dysfunction profiles.
Skills the Lab Values
cell culturebrain organoid developmentelectrophysiologycalcium sensor imaginggenetic mutation analysisdata analysis of neural oscillationsimaging techniquesexperimental designmolecular biology techniques
Output against the department
Publications84bottom 25% of dept.500th of 671
this lab
most publishedleast published
Citations10ktop 38% of dept.257th of 671
this lab
most citedleast cited
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