University of Minnesota-Twin Cities · Biomedical EngineeringAging Brain Imaging Lab
Silvia Mangia · Minneapolis, Minnesota
Research Focus
Dr. Silvia Mangia's lab focuses on understanding how brain function is affected by aging, specifically in relation to blood flow and metabolism. They develop and use innovative neuroimaging techniques to measure important brain metrics like oxygen and carbon dioxide levels, as well as pH, to see how these change in aging individuals. The goal is to uncover how these changes contribute to cognitive decline and to identify potential interventions for preserving brain health in older adults.
neurovascular couplingbrain metabolismagingfunctional neuroimagingcognitive healthcarbon dioxide accumulationMRIPETneuroimaging methodologieshomeostasis
Research Aims
3AIM 01Develop a computational model to assess brain pCO2, pO2, and pH levels in aging humans.
AIM 02Test neurovascular coupling and metabolic coupling during visual stimulation in elderly and young subjects.
AIM 03Investigate the impact of resting state fluctuations on brain metabolic homeostasis.
Skills the Lab Values
MRIPET imagingcalibrated fMRIfMRSdata modelingneuroimaging analysisbehavioral studiestheoretical modelingbioinformaticsmultimodal imaging
Output against the department
Publications180bottom 41% of dept.349th of 595
this lab
most publishedleast published
Citations4.9kbottom 37% of dept.374th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.