University of Washington-Seattle Campus · Microbiology & ImmunologyPepper Lab
Marion Pepper · Seattle, Washington
Research Focus
Dr. Marion Pepper's lab at the University of Washington studies how certain immune cells influence asthma, a common respiratory condition. The lab focuses on understanding specific types of memory T cells that respond to allergens found in house dust mites. By examining how these cells behave over time and in response to allergens, the research aims to uncover new ways to improve asthma treatments and prevent severe allergic reactions.
asthmaCD4+ T cellsallergen-specific immunitylung-resident memory T cellsimmunotherapyTh2 cellshouse dust mitecytokinesmemory T cell heterogeneity
Research Aims
5AIM 01Identify how different populations of Th2 memory T cells contribute to asthma pathogenesis.
AIM 02Examine the function and survival of allergen-specific memory T cells in the lung.
AIM 03Develop techniques to track and manipulate T cell populations for research.
AIM 04Investigate the molecular mechanisms maintaining T cell memory in lung tissues.
AIM 05Explore potential immunotherapeutic targets for treating allergic asthma.
Skills the Lab Values
flow cytometrycell culturemouse modelsMHC tetramer stainingimmunological assaysmagnetic bead cell enrichmentRNA sequencingdata analysis in immunologymicroscopy
Output against the department
Publications132top 49% of dept.238th of 486
this lab
most publishedleast published
Citations9.6ktop 38% of dept.184th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.