Loyola University Chicago · BiologyWainwright Immunotherapy Lab
Derek Alan Wainwright · Chicago, Illinois
Research Focus
Dr. Derek Alan Wainwright's research lab at Loyola University Chicago focuses on understanding glioblastoma, a type of brain tumor that evades the body's immune response. His team investigates a protein called indoleamine 23 dioxygenase 1 (IDO1), which plays a crucial role in suppressing the immune system in glioblastoma cases. They aim to develop innovative therapies that can enhance the immune response against this challenging cancer.
glioblastomaimmune responseIDO1immunotherapycancer researchT cell infiltrationIDO-PROTACsimmunosuppressionbrain tumors
Research Aims
4AIM 01Investigate the mechanisms of immune suppression by IDO1 in glioblastoma cells.
AIM 02Develop novel IDO-PROTACs for targeted depletion of IDO protein.
AIM 03Characterize the role of IDO1 in glioblastoma-induced T cell polarization.
AIM 04Optimize therapeutic strategies combining immunotherapy with IDO inhibitors.
Skills the Lab Values
cell culturemouse modelsflow cytometryWestern blotRNA sequencingprotein degradation techniquesxenograft modelsin vivo imagingmolecular cloning
Output against the department
Publications322top 16% of dept.168th of 1,033
this lab
most publishedleast published
Citations8.2ktop 46% of dept.479th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.