University of California-Irvine · BiologySchilling Skeletogenesis Lab
Thomas F Schilling · Irvine, California
Research Focus
Dr. Thomas F Schilling's lab at UC Irvine investigates how cells organize themselves during the development of the skeleton, particularly focusing on craniofacial bones. They aim to understand the signals that guide cartilage growth and alignment, which is crucial for normal bone formation. Insights from this research could lead to better treatments for skeletal disorders and congenital malformations.
cellular polaritycraniofacial developmentskeletogenesiscartilage growthDlx5Dlx6planar cell polaritystem cell therapyskeletal disorderscartilage morphogenesis
Research Aims
3AIM 01Investigate how Dlx5 and Dlx6 regulate cartilage cell alignment during early development.
AIM 02Examine the role of Wnt5 and Fat3 in the planar polarity of cartilage growth zones.
AIM 03Identify new genes affecting cartilage polarity using genetic mapping techniques.
Skills the Lab Values
genetic manipulationembryonic developmenttransgenic techniquesimaging techniquesquantitative trait locus mappingcell culturemolecular signaling assaysCRISPRdata analysisanimal models
Output against the department
Publications180top 37% of dept.379th of 1,033
this lab
most publishedleast published
Citations23ktop 17% of dept.175th of 1,033
this lab
most citedleast cited
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