University of Washington-Seattle Campus · GeneticsGenetic Interactions and Complex Traits Lab
Christine Queitsch · Seattle, Washington
Research Focus
Dr. Christine Queitsch's lab focuses on understanding how genetic variations interact with one another to influence complex traits and diseases. Using model organisms such as yeast and the roundworm Caenorhabditis elegans, her research aims to unravel the mechanisms behind these genetic interactions, particularly those involving repetitive DNA elements. By employing advanced genetic techniques and robotics, the lab investigates the impact of these interactions on phenotypes such as lifespan and fitness, contributing to our knowledge of human genetics and potential medical advancements.
genetic interactionsepistasisCaenorhabditis elegansSaccharomyces cerevisiaegenome stabilityhigh-throughput analysisrDNA polymorphismprotein interactionsmating efficiency
Research Aims
5AIM 01Identify genetic interactions that significantly impact complex phenotypes
AIM 02Characterize the role of ribosomal DNA copy number variation
AIM 03Test the effects of single nucleotide variant combinations on mating efficiency
AIM 04Explore the dynamics of protein interaction surfaces using dominant negative polypeptides
AIM 05Develop and optimize technologies for assessing genetic interactions in model organisms.
Skills the Lab Values
PCRgenotypingquantitative phenotypingrobotics in researchgenetic mappinghigh-throughput sequencingFISH techniquedata analysismodel organism studies
Output against the department
Publications136bottom 43% of dept.147th of 259
this lab
most publishedleast published
Citations7.7kbottom 43% of dept.148th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.