University of California-San Francisco · PharmacologyLiver Fibrosis Research Lab
Hyunil Jo · San Francisco, California
Research Focus
Dr. Hyunil Jo's lab at UCSF focuses on researching liver fibrosis, a severe condition that leads to liver failure. The lab is working on developing new drugs that target an enzyme called acid ceramidase, which has been shown to play a significant role in liver fibrosis. By creating potent inhibitors of this enzyme, they hope to provide effective treatments for patients suffering from chronic liver diseases, where current options are limited.
liver fibrosisacid ceramidasedrug developmenthepatologychronic liver disease
Research Aims
4AIM 01Identify covalent inhibitors of acid ceramidase with optimal properties for oral delivery.
AIM 02Test the efficacy of optimized compounds in mouse models of liver fibrosis.
AIM 03Evaluate drug metabolism and stability of candidate compounds for potential treatment of hepatic fibrosis.
AIM 04Develop a novel treatment strategy for patients with chronic liver disease.
Skills the Lab Values
medicinal chemistrymouse modelscell culturein vitro assaysbiochemical assays
Output against the department
Publications111bottom 30% of dept.324th of 462
this lab
most publishedleast published
Citations2.8kbottom 21% of dept.365th of 462
this lab
most citedleast cited
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