Northwestern University · PharmacologyThe KCNQ2 Project
Alfred L. George · Evanston, Illinois
Research Focus
Dr. Alfred L. George's lab at Northwestern University studies genetic causes of epilepsy, particularly focusing on disorders linked to the KCNQ2 gene. They aim to understand how mutations in this gene affect brain function and lead to different severity levels in epilepsy symptoms. The lab utilizes advanced technologies, including human stem cell models and genetically engineered mice, to explore these mechanisms, ultimately seeking to inform new treatments for affected patients.
KCNQ2epilepsyneurodevelopmental disordersiPSCgene mutationspotassium channelsmolecular mechanismspharmacological treatments
Research Aims
3AIM 01Determine how KCNQ2 mutations affect channel assembly in neurons.
AIM 02Investigate the composition of KV7 channels in human neurons using patient-derived lines.
AIM 03Examine the electrophysiological and pharmacological differences between KCNQ2 variants.
Skills the Lab Values
induced pluripotent stem cell (iPSC) culturegenetically engineered mouse modelselectrophysiologyimmunofluorescence microscopyWestern blottingRNA isolationPCRdata analysis in Rcellular localization studies
Output against the department
Publications565top 9% of dept.40th of 462
this lab
most publishedleast published
Citations36ktop 7% of dept.33rd of 462
this lab
most citedleast cited
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