Rutgers University-New Brunswick · BiologyCardiac Molecular Mechanisms Lab
Diego Fraidenraich · New Brunswick, New Jersey
Research Focus
Dr. Diego Fraidenraich's lab focuses on understanding how certain proteins in heart cells, particularly Connexin 43, are affected by Duchenne muscular dystrophy (DMD), a severe genetic disorder. The research explores how these changes contribute to heart problems associated with DMD and aims to develop new therapeutic strategies to protect heart function in affected patients. By utilizing advanced molecular techniques, the lab seeks to identify and manipulate the pathways that lead to cardiac complications in DMD.
Duchenne muscular dystrophycardiomyopathyConnexin 43microtubulesphosphorylationcardiac functionfibrosisreactive oxygen species
Research Aims
4AIM 01Investigate the role of Connexin 43 in cardiac pathology related to Duchenne muscular dystrophy.
AIM 02Examine the interactions between Connexin 43 and the microtubule cytoskeleton.
AIM 03Assess how modifications in Connexin 43 can influence heart cell function and stability.
AIM 04Identify potential therapeutic targets to improve cardiac health in DMD patients.
Skills the Lab Values
cell culturemolecular cloningWestern blotimmunofluorescence microscopyelectrophysiologygene editingprotein analysisfluorescence microscopybiochemical assays
Output against the department
Publications74bottom 21% of dept.812th of 1,033
this lab
most publishedleast published
Citations1.9kbottom 12% of dept.904th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.