Johns Hopkins University · Microbiology & ImmunologyCellular Senescence and Tissue Mapping Lab
Pei-Hsun Wu · Baltimore, Maryland
Research Focus
Dr. Pei-Hsun Wu's lab at Johns Hopkins University focuses on understanding cellular senescence, especially in the context of aging and age-related diseases. By creating three-dimensional maps of tissues like the pancreas, breast, and ovaries, the lab aims to explore how senescent cells are distributed and how they contribute to various disorders. Their innovative approaches combine advanced imaging techniques and molecular profiling to uncover the complexities of these cells within human tissues.
cellular senescence3D tissue mappingage-related diseasesspatial transcriptomicsimmunofluorescence
Research Aims
5AIM 01Map the spatial distribution of senescent cells in human pancreas and breast tissue.
AIM 02Develop an integrated platform combining AI for tissue imaging and molecular analysis.
AIM 03Create a comprehensive 3D senescence atlas for pancreatic, breast, and ovarian tissues across different ages.
AIM 04Identify molecular signatures associated with senescent cells in various tissue compartments.
AIM 05Investigate the role of cellular senescence in aging and related diseases.
Skills the Lab Values
3D imagingimmunofluorescencetissue reconstructionRNA sequencingspatial transcriptomics
Output against the department
Publications411top 9% of dept.43rd of 486
this lab
most publishedleast published
Citations41ktop 5% of dept.26th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.